Antioxidant Activity of Flavolignans from Silybum marianum (L). Gaertn. Fruits
نویسنده
چکیده
The flavolignans silybin (1) and 2,3-dehydrosilybin (2) (Figure 1) were isolated from fruits of milk thistle [Silybum marianum (L). Gaertn.] cultivated in the Samara region (Russian Federation). 2,3-dehydrosilybin (2) for the first time in Russian Federation is described for the given plant. Silybin and 2,3-dehydrosilybin and also new preparation, a fluid extract of Silybum marianum fruits, have expressed antioxidant activity, decreasing the level of the lipid peroxidation caused FeSO4 in the homogenate of a rat liver. The antioxidant activity of 2,3-dehydrosilybin is reported for the first time and on 14.0% above those of silybin. The discovery of the antioxidant activity for 2,3-dehydrosilybin allows in a new fashion to discuss the contribution of flavolignans in biological activity of hepatoprotective remedies on the basis of Silybum marianum drugs.
منابع مشابه
Influence of Plant Growth Regulators on Callus Induction, Silymarin Production and Antioxidant Activity in Milk Thistle (Silybum marianum L. Gaertn.) under Tissue Culture Medium
The Silybum marianum (L.) Gaertn. is the dicotyledonous herbs of the Asteraceae family that is important in medical industry. The biological active compound of S. marianum is a mixture of several flavonolignals generally known as silymarin. The purpose of this study was to optimize S. marianum tissue culture for callus induction, silymarin production and comparison of some biochemical traits be...
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